Introduction to mammalian physiology from an engineering point of view. The quantitative aspects of normal cellular and organ functions and the regulatory processes required maintaining organ viability and homeostasis. Laboratory exercises using exercise physiology as an integration of function at the cellular, organ and systems level will be conducted at the same time. Measurements of heart activity (EKG), cardiac output (partial CO2 rebreathing), blood pressure, oxygen consumption, carbon dioxide production, muscle strength (EMG), fluid shifts and respiratory function in response to exercise stress will be measured and analyzed from an engineering point of view.
Time and frequency domain analysis of linear control systems. Proportional, derivative and integral control actions. Stability. Applications of control theory to physiological control systems: biosensors, information processors and bioactuators. Mathematical modeling and analysis of heart and blood pressure regulation, body temperature regulation, regulation of intracellular ionic concentrations, eye movement and pupil dilation controls. Use of Matlab and Simulink to model blood pressure regulation, auto regulation of blood flow, force development by muscle contraction, and integrated response of cardiac output, blood pressure and respiration to exercise.
Introduction to mammalian physiology from an engineering point of view. The quantitative aspects of normal cellular and organ functions and the regulatory processes required to maintain organ viability and homeostasis. Laboratory exercises using exercise physiology as an integration of function at the cellular, organ and systems level will be conducted at the same time. Measurements of heart activity (EKG), cardiac output (partial CO2 rebreathing), blood pressure, oxygen consumption, carbon dioxide production, muscle strength (EMG), fluid shifts and respiratory function in response to exercise stress will be measured and analyzed from an engineering point of view.
One of the distinguishing features of biomedical engineers is the ability to make and interpret measurements on living systems. One of the major objectives of advanced laboratory training is to provide experience in selecting appropriate measurement and analysis tools that will advance hypothesis driven and translational research and development. This laboratory serves these dual purposes. Students are introduced to techniques for measurements at the cellular, organ and systems levels. Students will then use these techniques to: a) formulate hypotheses, design experiments using the tools provided, make appropriate measurements, analyze the data an determine if the data do or do not support their hypotheses; b) make measurements that facilitate the design and manufacture of devices in terms of materials properties, fatigue and failure modes. Each student will keep a laboratory notebook.
BME 655:Principles of Multiscale Biosystems Development and Integration
This course extends concepts present in tissue engineering, biotransport and biomaterial to develop design principles for generating tissue and organs in-vitro. The processes which cells integrate proteins and extracellular matrix to form functioning organ systems are developed. The principles of bioreactor design are sued to analyze and design in-vitro systems for growing functioning tissue and organs for use as prostheses. Principles of Scale-up to organs of different size are discussed. Design issues and limitations for extension of these principles to multi-organ systems are illustrated.
Schaefer School of Engineering & Science
Chemistry, Chemical Biology & Biomedical Engineering
Research & Education
The City University of New York, BChE
The University of Rochester, MChE
The University of Rochester, PhD
Mathematical Modeling of Physiological Systems, Angiotensin Converting Enzyme (ACE) and Cardiac Myocytes, The Failing Heart, Pulsatile Flow in Distensible Vessels, Rotary Protein Motors.
Experience & Service
Dr. Ritter received his BChE degree from the City College of New York, and his MS and PhD degrees in ChE from the University of Rochester. Before returning for his PhD degree he had over 10 years of industrial experience in the aerospace industry for the US Navy and United Aircraft in solid rocket propellant development and as a development engineer for the Mixing Equipment Company and the DuPont Co. His first academic appointment was at Stevens Institute of Technology in the department of Chemistry and Chemical Engineering where he did research on solar energy storage and conversion and optimal control of chemical processes. He taught courses in transport phenomena and process control. While at Stevens he met Francis Chinard, MD from UMD-New Jersey Medical School and started collaborative research in pulmonary transport and metabolism in-vivo. This led to a full time position in Dr. Chinard’s lab in the department of Medicine at NJMS. After a few years he was recruited to the department of Physiology where he spent the next 20 years teaching Cardiovascular and Respiratory physiology, statistics for the life sciences and physical chemistry to Medical, Dental and Graduate students. His research areas were microcirculatory and cardio-respiratory physiology. He was course director of the medical physiology course for 5 years before returning to Stevens to start the Biomedical Engineering program. He still maintains an adjunct appointment at NJMS. He was the PI or Co-PI on grants from NSF, NIH, AHA and New Jersey Commission on Science and Technology.
Dr. Ritter has mentored of 7 PhD students in Physiology and Biomedical Engineering and over 40 Masters student’s in Biomedical Engineering.
He is the co-author of over 40 publications in peer reviewed journals and numerous abstracts and presentations at local, national and international conferences. He is the primary author of a recent undergraduate textbook in Biomedical Engineering.
His current research interests are in Systems Physiology, Rotary Protein Motors and The Failing Heart.
U.S. Naval Propellant Plant, Indian Head, MD, Development Engineer
United Aircraft, UTC Division, Sunnyvale, CA, Development Engineer
Mixing Equipment Co., Rochester, N.Y., Research Engineer
E.I. Dupont, Photo products Div., Parlin, NJ, Research Engineer
Dept. of Medicine, UMD-New Jersey Medical School, Adjunct Assistant Prof.
Dept. of Pharmacology and Physiology, UMD-New Jersey Medical School, Assistant and Associate Professor (tenured). Retired,2003.
Adjunct Professor of Pharmacology and Physiology, UMD-New Jersey Medical School.
Achievements & Professional Societies
Patents & Inventions
No. 6,324,419. 2001.
Inventors: A. Nejat Guzelsu, Thomas W. Findley, John Federici, Hans Chaudhry, Arthur B. Ritter. Title: Apparatus and Method for Non-Invasive Measurement of Stretch.
Microcirculatory Society, Inc., ASEE, BMES
Ritter, A. B., Reisman, S., Michniak. B.B.. (2005). Biomedical Engineering Principles, Taylor & Francis Group, CRC Press, Boca Raton, Fl. ISBN # 0-8247-9616-0.
. Bekker, A., Wolk, S., Turndorf, H., Kristol, D. and Ritter, A.B.. (1996). "Computer simulation of cerebrovascular circulation, assessment of intracranial hemodynamics during induction of anesthesia", . J. Clinical Monitoring, 12 433 - 444.
Chaudhry, H.R., Bukiet, B., Siegel, M., Findley, T, Ritter, A.B., and Guselsu, N.. (1999). "Adaptation of passive rat left ventricle in diastolic dysfunction", J. Theoretical Biology, 201 37 - 46.
Chaudhry, H.R., Bukiet, B.B., Ritter, A.B., and Arora, R. (2002). "Mechanical Properties of Diseased Hearts During Adaptation.", Journal of Mechanics in Biology and Medicine , 2 (No. 2) 165 - 176.
Guzelsu, N., Federici, J.F., Lim, H.C., Chaudhry, H.R., Ritter, A.B., Findley, T.. (2003). "Measurement of skin stretch via light reflection. ", Journal of Biomedical Optics , 8(1) 80 - 86.
Hazelwood, V., Madjanska, J., Ritter, A.B.. (2007). "Do College Students Benefit from School Required Activity? A Clinical Trial", Medicine and Science in Sports and Exercise, 39 5S.
Hazelwood, V., Wisniewski, H., Ritter, A.B.. (2007). "Entrepreneurship in Biomedical Senior Design, from Classroom to Corporation,", International Conference on Engineering Education, Annual Symposia, Coimbra Portugal, September 2007.
Desiderio, M., Atlas, G.M., Ritter, A.B. (2007). ". A Non-Invasive Dual Doppler Technique for Aortic Volume: An Evaluation of the Bramwell-Hill Equation", BMES National Meeting, Sept., 2007.. Springer.