Introduction to mammalian physiology from an engineering point of view.  The quantitative aspects of normal cellular and organ functions and the regulatory processes required maintaining organ viability and homeostasis.  Laboratory exercises using exercise physiology as an integration of function at the cellular, organ and systems level will be conducted at the same time. Measurements of heart activity (EKG), cardiac output (partial CO2 rebreathing), blood pressure, oxygen consumption, carbon dioxide production, muscle strength (EMG), fluid shifts and respiratory function in response to exercise stress will be measured and analyzed from an engineering point of view.

Time and frequency domain analysis of linear control systems. Proportional, derivative and integral control actions.  Stability. Applications of control theory to physiological control systems: biosensors, information processors and bioactuators.  Mathematical modeling and analysis of heart and blood pressure regulation, body temperature regulation, regulation of intracellular ionic concentrations, eye movement and pupil dilation controls.  Use of Matlab and Simulink to model blood pressure regulation, auto regulation of blood flow, force development by muscle contraction, and integrated response of cardiac output, blood pressure and respiration to exercise.

Introduction to mammalian physiology from an engineering point of view.  The quantitative aspects of normal cellular and organ functions and the regulatory processes required to maintain organ viability and homeostasis.  Laboratory exercises using exercise physiology as an integration of function at the cellular, organ and systems level will be conducted at the same time. Measurements of heart activity (EKG), cardiac output (partial CO2 rebreathing), blood pressure, oxygen consumption, carbon dioxide production, muscle strength (EMG), fluid shifts and respiratory function in response to exercise stress will be measured and analyzed from an engineering point of view.

One of the distinguishing features of biomedical engineers is the ability to make and interpret measurements on living systems.  One of the major objectives of advanced laboratory training is to provide experience in selecting appropriate measurement and analysis tools that will advance hypothesis driven and translational research and development.  This laboratory serves these dual purposes.  Students are introduced to techniques for measurements at the cellular, organ and systems levels. Students will then use these techniques to: a) formulate hypotheses, design experiments using the tools provided, make appropriate measurements, analyze the data an determine if the data do or do not support their hypotheses; b) make measurements that facilitate the design and manufacture of devices in terms of materials properties, fatigue and failure modes.  Each student will keep a laboratory notebook.

This course extends concepts present in tissue engineering, biotransport and biomaterial to develop design principles for generating tissue and organs in-vitro.  The processes which cells integrate proteins and extracellular matrix to form functioning organ systems are developed.  The principles of bioreactor design are sued to analyze and design in-vitro systems for growing functioning tissue and organs for use as prostheses. Principles of Scale-up to organs of different size are discussed.  Design issues and limitations for extension of these principles to multi-organ systems are illustrated.