PME 649:Design of Water, Steam and CIP Utility Systems for Pharma Manufacturing
Water & steam systems: (water used as excipient, cleaning agent, or product diluent) water quality selection criteria; generation, storage, and distribution systems; bio-burden control; USP PWS (purified water systems) and USP WFI (water for injection) systems; engineering considerations, including specification, design, installation, validation, operation, testing, and maintenance; common unit operations, including deionization, reverse osmosis, distillation, ultrafiltration, and ozonation systems; process considerations, including pretreatment, storage and distribution, materials of construction, microbial control, pyrogen control, and system maintenance; FDA requirements; clean-in-place systems; and steam generation and distribution systems.
Schaefer School of Engineering & Science
Department:
Mechanical Engineering
Program:
Pharmaceutical Manufacturing Engineering
William V. Collentro is Senior Consultant and founder of Water Consulting Specialists, Inc. Mr. Collentro's career spans over forty years in the area of water treatment and purification, principally for the life sciences. In addition to being an adjunct Professor at Stevens Institute of Technology, Mr. Collentro is an adjunct professor for the Parenteral Drug Association's Training and Research Institute where he was awarded the James P. Agalloco Award for Excellence in Training in 1998. Mr. Collentro has authored a text, Pharmaceutical Water, System Design, Operation and Validation, as well as chapters for other texts on pharmaceutical water. He also holds two patents for membrane based water purification applications, and participates in periodic technical conferences each year. Mr. Collentro is a member of several professional organizations including AIChE, ACS, PDA and AWWA. He received both a B.S. and M.S. in Chemical Engineering from Worcester Polytechnic Institute.
Experience & Service
General Information
William V. Collentro is Senior Consultant and founder of Water Consulting Specialists, Inc. Mr. Collentro's career spans over forty years in the area of water treatment and purification, principally for the life sciences. In addition to being an adjunct Professor at Stevens Institute of Technology, Mr. Collentro is an adjunct professor for the Parenteral Drug Association's Training and Research Institute where he was awarded the James P. Agalloco Award for Excellence in Training in 1998. Mr. Collentro has authored a text, Pharmaceutical Water, System Design, Operation and Validation, as well as chapters for other texts on pharmaceutical water. He also holds two patents for membrane based water purification applications, and participates in periodic technical conferences each year. Mr. Collentro is a member of several professional organizations including AIChE, ACS, PDA and AWWA. He received both a B.S. and M.S. in Chemical Engineering from Worcester Polytechnic Institute.
