B.S.,Chemical Engineering, University of Pennsylvania, Philadelphia, PA, 2000
Research
Biofabrication
Computer-Aided Tissue Engineering
Biomimetic Tissue-Based Design
Microscale In vitro Physiological/Pathological Systems
Mechanobiology/Mechanosensing
Optical Medical Imaging
Biomedical Devices
Experience & Service
Professional Service
Reviewer for: ASME Journal of Biomechanical Engineering, NIST WERB
Reviewer for: NIST ARRA Grant Proposal
Session Co-chair for MSEC Symposium
Session Co-chair for TERMIS
Experience
8/12-present, Assistant Professor, Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ
7/11-8/12, Biomechanical Engineer, Division of Radiation and Biomolecular Physics, Physical Measurement Lab, National Institute of Standards and Technology, Gaithersburg, MD
7/09-7/11, NRC Postdoctoral Fellow, Division of Optical Technology, Physical Measurement Lab, National Institute of Standards and Technology, Gaithersburg, MD
12/04-7/09, Graduate Research Assistant, Computer-Aided Tissue Engineering Lab, Drexel University, Philadelphia, PA
Achievements & Professional Societies
Honors & Awards
Sigma Xi NIST Best Poster Award in Mathematics and Engineering, 2011
National Research Council (NRC) Postdoctoral Associateship Award, 2009
Drexel’s Best Dissertation Award in Mathematics and Engineering, 2009
Drexel’s Graduate Research Award, 2009
NASA Tech Brief Award, 2009
NSF CMMI Research and Innovation Conference Student Award, 2009
BP Young Scientists and Students Award (YSSA), 2008
NASA Technology Transfer Award, 2008
GAANN Fellowship, 2006-2007
Patents & Inventions
Patent Pending: “Bioprinting Three-Dimensional Polymeric Hydrogel Structures Onto Microscale Tissue Analog Devices for Pharmacokinetic Study,” D2027/20052 (co-inventors B Starly, J Nam, W Sun).
Patent Pending: “Micro-Organ Device,” NASA Case No. MSC-23988-1 (co-inventors S Gonda, H Holtorf, B Starly, J Nam, W Sun).
Provisional Patent Filed: “Bioprinting Cell-laden Constructs for Multicompartment Tissue Chambers,” 46528-6016-P1-US (co-inventors J Snyder , W Sun).
Provisional Patent Filed: “Multilayered Optical Tissue Phantom Using Buried Scattering Microspheres in Polymer Layers,” 61/582,858 (co-inventors C Stafford, J Hwang)
Professional Societies
Member, American Society of Mechanical Engineers (ASME)
Member, International Society of Optics and Photonics (SPIE)
Selected Publications
Journals
Chang R., Johnson P., Stafford C., and Hwang J.. (2012). "Fabrication and Characterization of a Multilayered Optical Tissue Model with Embedded Scattering Microspheres in Polymeric Materials", Biomedical Optics Express, 6 (3), 1326-1339.
Litorja M., Chang R., Hwang J., Allen D., Zuzak K., Wehner E., Best S., Livingston E., and Caddedu J.. (2012). "Calibration and validation scheme for in vivo spectroscopic imaging of tissue oxygenation", Oxygen Transport to Tissue XXXIV, Advances in Experimental Biology and Medicine (New York, NY).
Lee J.Y., Clarke M.L., Tokumasu F., Lesoine J.F., Allen D.W., Chang R., Litorja M., and Hwang J.. (2011). "Absorption-Based Hyperspectral Imaging and Analysis of Single Erythrocytes", IEEE Journal of Selected Topics in Quantum Electronics, (99), 1-10.
Chang R., Emami K., Jeevarajan A., Wu H., and Sun W.. (2011). "Direct Cell Writing of 3D Micro-organ for Drug Metabolism Studies", Biofabrication, 4 (2), 1-11.
Chang R., Nam J., and Sun W.. (2008). "Direct Cell Writing of 3D Micro-organ for In Vitro Pharmacokinetic Model", Tissue Engineering Part C, 2 (14), 157-169.
Chang R., Nam J., and Sun W.. (2008). "Computer-Aided Design, Modeling, and Freeform Fabrication of Micro-organ Flow Patterns for Pharmacokinetic Study", CAD Applications, 5 21-29.
Chang R., Nam J., and Sun W.. (2008). "Effects of Dispensing Pressure and Nozzle Diameter on Cell Survival from Solid Freeform Fabrication-based Direct Cell Writing", Tissue Engineering, 1 (14), 41-48.
Buyukhatipoglu K., Chang R., Sun W., and Morss Clyne A.. (2010). "Bioprinted Nanoparticles for Tissue Engineering Applications", Tissue Engineering Part C, 4 (16), 631-642.
Shor L., Guceri S., Chang R., Sun W., Gordon J., Kang Q., Hartstock L., and An Y.. (2009). "Precision Extruding Deposition (PED) Fabrication of Poly-e-Caprolactone (PCL) Scaffolds for Bone Tissue Engineering", Biofabrication, 1 (1), 1-10.
Conference Proceedings
Chang R., Johnson P., Stafford C., and Hwang J.. (Jan 21-26, 2012). "Fabrication and Characterization of a Multilayered Optical Phantom Using Buried Scattering Microspheres in Polymers", SPIE Symposium on SPIE BiOS: Biomedical Optics. San Francisco, CA.
Chang R., Clarke M., and Hwang J.. (Jan 22-27, 2011). "Hyperspectral Imaging Characterization for a Perfused Oximetry Phantom", SPIE Symposium on SPIE BiOS: Biomedical Optics. San Francisco, CA.
Chang R., Hwang J., Agrawal A., Johnson P., and Stafford C.. (Feb 13-16, 2011). "OCT for Depth Detection of Buried Particles in Polymeric Materials", The Adhesion Society Annual Meeting & Expo. Savannah, GA.
Allen D.W., Maxwell S., Rice J., Chang R., Litorja M., Hwang J., Wehner E., Zuzak K.J.. (Jan 22-27, 2011). "Hyperspectral image projection of a pig kidney for the evaluation of imagers used for oximetry", SPIE Symposium on SPIE BiOS: Biomedical Optics. San Francisco, CA.
Lee J.Y., Lesoine J.F., Krogmeier J.R., Kang H., Clarke M., Chang R., Sackett D.L., Nossal R., and Hwang J.. (Jan 22-27, 2011). "Real-time fluorescence polarization microscopy for probing local distributions of biomolecules", SPIE Symposium on SPIE BiOS: Biomedical Optics. San Francisco, CA.
Lee J.Y., Clarke M.L., Tokumasu F., Lesoine J.F., Allen D.W., Chang R., Litorja M., and Hwang J.. (Jan 23-28, 2010). "Direct Cell Writing 3D Tissue-on-a-Chip as an In Vivo Tissue Analog in Optical Imaging", SPIE Symposium on SPIE BiOS: Biomedical Optics. San Francisco, CA.
Snyder J., Roy D., Chang R., Bergenstock M., Liu Q. and Sun W.. (Nov 13-19, 2009). "Solid Freeform Fabrication for Biomimetic Tissue Constructs", ASME IMECE conference. Lake Buena Vista, FL, USA.
Chang R., Snyder J., Wu H. and Sun W.. (Aug 31, 2009). "Bioprinting Cell-Laden Matrigel Constructs for Multicompartment Tissue Chambers", 2nd World Congress of Tissue Engineering and Regenerative Medicine. Seoul, Korea.
Buyukhatipoglu K., Chang R., Clyne A., Sun, W.. (May 11-13, 2009). "Bioprinting Nanoparticles for Tissue Engineering", Conference on Computational Intelligence for Measurement Systems and Applications (CIMSA). Hong Kong, China.
Chang R., Snyder J., Wu H., and Sun W.. (Jul 9-11, 2009). "Bioprinting Cell-Embedded Matrigel Tissue Constructs for Micro-organ Devices", ECCOMAS International Conference on Tissue Engineering. Leiria, Portugal.
Snyder J., Chang R., Roy D., and Sun W.. (Jun 17-21, 2009). "Solid Freeform Fabrication for Bio-mimetic 3D Tissue Constructs", ASME Summer Bioengineering Conference. La Tahoe, CA.
Chang R., Liu Q., Lau W., and Sun W.. (Dec 13-17, 2008). "3D Cell Culture for Enhancement of Cell Function", The American Society for Cell Biology (ASCB). San Francisco, CA.
Chang R., Liu Q., Lau W., and Sun W.. (Dec 9-13, 2008). "3D Scaffolds for Enhanced Cell Culture and Tissue Engineering Applications", Tissue Engineering and Regenerative Medicine North America. San Diego, CA.
Chang R., Nam J., Holtorf H., Emami K., Gonda S., Jeevarajan A., Wu H., and Sun W.. (Oct 12-17, 2008). "Direct Cell Writing of 3D Tissue Micro-organs for Drug Metabolism Study", 13th International Biotechnology Symposium & Exhibition. Dalian, China.
Chang R., Nam J., Morss-Clyne A., and Sun W.. (May 23-28, 2008). "Direct Cell Writing of Cell Encapsulated 3D Liver Tissue Constructs Patterned With Endothelial Cells", 8th World Biomaterials Congress. Amsterdam, Holland.
Holtorf H., Leslie J., Chang R., Nam J., Culbertson C., Sun W., Gonda S.. (Dec 1-5, 2007). "Development of a Three-Dimensional Tissue-on-a-Chip Micro-Organ Device for Pharmacokinetic Analysis", 47th Annual Meeting of the American Society for Cell Biology. Washington, DC.
Chang R., Nam J., Holtorf H., Jeevarajan A., Gonda S., Culbertson C., and Sun W.. (Oct 15-18, 2007). "Biofabrication of Liver Tissue Constructs on a Microfluidic Platform for Pharmacokinetic Study", International Manufacturing Science and Engineering. Atlanta, GA, USA.
Chang R., Nam J., Holtorf H., Jeevarajan A., Gonda S., Culbertson C. and Sun W.. (Oct 15-18, 2007). "Biofabrication of Liver Tissue Constructs on a Microfluidic Platform for Pharmacokinetic Study", ASME International Manufacturing Science and Engineering. Atlanta, Georgia, USA.
Chang R., Nam J., and Sun W.. (Aug 6-8, 2007). "Direct Cell Writing for Freeform Biofabrication of 3D Pharmacokinetic Models", 18th Solid Freeform Fabrication Symposium. Austin, TX, USA.
Chang R., Nam J., and Sun W.. (Jun 18-20, 2007). "Freeform Biofabrication of Hepatocellular Tissue Constructs as an In Vitro Physiological Model", Flexible Automation and Intelligent Manufacturing (FAIM). Philadelphia, PA, USA.
Chang R., Sun W., Culbertson C., Holtof H., and Gonda S.. (Jun 13-16, 2007). "Design and Modeling of Flow Patterns for Cell Encapsulated 3D Liver Tissue-on-chip as a Pharmacokinetic Study Platform", Tissue Engineering and Regenerative Medicine North America. Toronto, ON, Canada.
Chang R., Nam J., Culbertson C., Holtorf H., Jeevarajan A. and Sun W.. (Nov 21-22, 2006). "Computer-Aided Freeform Bioprinting of 3D Tissue Constructs for Pharmacokinetic Study", 3rd International Symposium on Bioprinting and Biofabrication. Kawasaki, Japan.
Chang R., Starly B., and Sun W.. (Aug 14-16, 2006). "Integration of Liver Encapsulated Alginate Hydrogels onto a Microfluidic Platform Using Freeform Fabrication", 17th Solid Freeform Fabrication Symposium. Austin, TX, USA.
Chang R., Starly B., Culbertson C., Holtof H., Gonda S., and Sun W.. (Apr 1-2, 2006). "Development of an in vitro Micro-organ Model for Pharmacokinetic Microanalysis", IEEE Northeast Bioengineering Conference. Lafayette College, Easton, PA, USA.
Starly B., Chang R., Sun W., Culbertson C., Holtof H., and Gonda S.. (Apr 24-27, 2006). "Bioprinted Tissue-on-chip Application for Pharmacokinetic Studies", World Congress on Tissue Engineering and Regenerative Medicine. Pittsburgh, PA, USA.
Starly B., Chang R., Sun W.. (Aug 14-16, 2006). "Fabrication of Hepatocyte Encapsulated Poly-Ethylene Glycol Hydrogels Using UV-Photolithography", 17th Solid Freeform Fabrication Symposium. Austin, TX, USA.
Book Chapters
Chang R., Nam J., Holtorf H., Emami K., Gonda S., Jeevarajan A., Wu H., and Sun W.. "A Case Study on 3D Bioprinted Liver Micro-organ as a Drug Metabolism Model", Ola Harrysson, SME Rapid Technologies/Additive Manufacturing for Medical Applications.
Chang R., Emami K., Jeevarajan A., Wu H., and Sun W.. (2011). "Microprinting of Liver Micro-organ for Drug Metabolism Study", Biological Microarrays: Methods and Protocols, Ali Khademhosseini, Kahp-Yang Suh and Mohammed Zourob, Methods in Molecular Biology 671, Humana Press. ISBN: 978-1-934115-95-4. 219-237.
Yildirim E., Chang R., Sun W.. "Biomanufacturing PCL Scaffolds and Cell-Integrated Constructs", Drs. James J. Yoo and Anthony Atala, The Handbook of Enabling Technologies for Regenerative Medicine.
Yildirim E., Ayan H., Chang R., Sperling M., Gorniak R., Guceri, S. and Sun W.. "Case 3.6: RP Assisted Mapping Epileptic Regions of Brain for Invasive Intracranial Electroencephalography", Ola Harrysson, SME Rapid Technologies/Additive Manufacturing for Medical Applications.
Books
Chang, R. and Sun, W.. (2009). Biofabrication of three-dimensional liver cell-embedded tissue constructs for in vitro drug metabolism models, LAP Lambert Academic Publishing. ISBN: 978-3-8383-2150-9.
